Pegylated long-acting interferon alfa-2b
Ropeginterferon alfa-2b (Specialist drug)
Brand names: Besremi
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: SC
Frequency: every 2-4 weeks
Clinical pearls
- Polycythaemia vera in adults without symptomatic splenomegaly
- Specialist haem
Contraindications
- Severe psychiatric disorder
- Severe hepatic/renal impairment
- Autoimmune disease (uncontrolled)
- Pregnancy
Side effects
- Flu-like syndrome
- Depression/suicidality
- Cytopenias
- Hepatotoxicity
- Autoimmune disorders (thyroid, lupus)
- Retinopathy
Interactions
- Theophylline
- Methadone
- CYP1A2 substrates
Monitoring
- FBC
- LFTs
- TFTs
- Mood
- Eye exam
Reference: BNF; NICE TA757; SmPC; https://bnf.nice.org.uk/drugs/ropeginterferon-alfa-2b-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Vancomycin Dosing Calculator · Drug Dosing
- Phenytoin Correction for Albumin / Renal Failure · Drug Dosing
- Local Anaesthetic Maximum Dose Calculator · Drug Dosing
- Corrected QT Interval (Bazett) · ECG
- Tisdale Risk Score for QT Prolongation · Arrhythmia
- Bazett Corrected QT Interval (QTc) Calculator · Arrhythmia
Pathways
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO
- Anticoagulation Reversal · BSH 2016 / ESC