Fifth-generation cephalosporin (anti-MRSA)
Ceftaroline fosamil
Brand names: Zinforo
Adult dose
Dose: 600mg IV q12h
Route: IV
Frequency: q12h
Clinical pearls
- BSAC: MRSA cover within cephalosporin class
- ABSSSI / community-acquired pneumonia (UKHSA AMR — restricted)
- Off-label for MRSA bacteraemia / endocarditis (specialist microbiology)
Contraindications
- Severe beta-lactam hypersensitivity
Side effects
- GI upset
- Hypersensitivity
- C. difficile
- Eosinophilia
- Direct Coombs positivity
Interactions
- Limited
Monitoring
- Renal function
- C. diff
- Coombs
Reference: BNF; BSAC; UKHSA AMR; SmPC; https://bnf.nice.org.uk/drugs/ceftaroline-fosamil/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Vancomycin Dosing Calculator · Drug Dosing
- Revised Original International Autoimmune Hepatitis Score (IAIHG) · Autoimmune Liver Disease
- Ho Index for Predicting Response to Medical Therapy in IBD · Inflammatory Bowel Disease
- Rh(D) Immune Globulin Dosage for Maternal-Fetal Haemorrhage · Haematology in Pregnancy
- AREDS Classification of Age-related Macular Degeneration · Macular Degeneration
- Diabetic Macular Oedema (DMO) Classification · Diabetic Retinopathy
Pathways
- Infective Endocarditis · ESC 2023 Infective Endocarditis Guidelines; NICE NG41
- Eczema Herpeticum · BAD; NICE CKS
- Suspected Bacterial Meningitis (Adult) · NICE NG240 (2024); NICE NG143 (paeds)
- Clostridioides difficile Colitis · NICE NG199 (2021); IDSA/SHEA 2021
- Returning Traveller — Fever · NaTHNaC; PHE; ESCMID 2018
- Malaria — Diagnosis & Management · PHE 2016; WHO 2023