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Single-tablet HIV regimen (PI + booster + 2× NRTI)

Darunavir with cobicistat, emtricitabine and tenofovir alafenamide

Brand names: Symtuza

Adult dose

Dose: 1 tablet OD with food
Route: Oral
Frequency: OD

Clinical pearls

  • BHIVA-recommended option, especially for treatment-experienced patients
  • TAF preferred for renal/bone protection

Contraindications

  • Severe hepatic impairment
  • CrCl <30
  • Concurrent strong CYP3A4 inducers
  • Hypersensitivity

Side effects

  • GI upset
  • Lipid changes
  • Mild creatinine increase (cobicistat)
  • HBV flare on discontinuation

Interactions

  • Many — cobicistat-mediated

Monitoring

  • VL/CD4
  • Renal function
  • LFTs
  • Lipids
  • HBV serology
  • Drug interactions

Reference: BNF; BHIVA HIV guidelines; EACS; https://bnf.nice.org.uk/drugs/darunavir-with-cobicistat-emtricitabine-and-tenofovir-alafenamide/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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