Combined HRT (oestrogen + progestogen)
Estradiol with medroxyprogesterone
Brand names: Indivina, Tridestra
Adult dose
Dose: 1 tablet OD per pack regimen
Route: Oral
Frequency: OD
Clinical pearls
- Medroxyprogesterone progestogen — observational data suggest higher breast cancer risk vs micronised progesterone (consider alternative)
- NICE NG23 review of progestogen choice
Contraindications
- Standard HRT contraindications
Side effects
- Breast tenderness
- Bleeding
- Mood changes
- VTE
- Breast cancer risk
Interactions
- CYP3A4 inducers
Monitoring
- BP
- Bleeding pattern
- Breast awareness
Reference: BNF; NICE NG23; British Menopause Society; https://bnf.nice.org.uk/drugs/estradiol-with-medroxyprogesterone/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
Pathways
- Spinal Anaesthesia Hypotension Management · AAGBI; ASA
- Pre-Eclampsia / Eclampsia in ED · NICE NG133; RCOG Green-top 10A
- Suspected Ectopic Pregnancy · NICE NG126; RCOG Green-top 21
- Polycystic Ovary Syndrome (PCOS) · International PCOS Guideline 2023; NICE CKS
- Pre-eclampsia Management · NICE NG133 2019
- Ectopic Pregnancy · NICE CG154 / RCOG GTG 21