Combined HRT (oestrogen + progestogen)
Estradiol with norethisterone
Brand names: Kliovance, Novofem, Elleste Duet, Evorel Conti, Evorel Sequi
Adult dose
Dose: 1 tablet OD or 1 transdermal patch twice weekly per regimen
Route: Oral / Transdermal
Frequency: OD or twice weekly
Clinical pearls
- Norethisterone-based HRT widely used; transdermal Evorel Conti/Sequi preferred if VTE risk
- NICE NG23
Contraindications
- Standard HRT contraindications
Side effects
- Breakthrough bleeding
- Breast tenderness
- Headache
- VTE (oral)
- Breast cancer risk
Interactions
- CYP3A4 inducers
Monitoring
- BP
- Bleeding pattern
- Breast awareness
Reference: BNF; NICE NG23; British Menopause Society; https://bnf.nice.org.uk/drugs/estradiol-with-norethisterone/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
Pathways
- Spinal Anaesthesia Hypotension Management · AAGBI; ASA
- Pre-Eclampsia / Eclampsia in ED · NICE NG133; RCOG Green-top 10A
- Suspected Ectopic Pregnancy · NICE NG126; RCOG Green-top 21
- Polycystic Ovary Syndrome (PCOS) · International PCOS Guideline 2023; NICE CKS
- Pre-eclampsia Management · NICE NG133 2019
- Ectopic Pregnancy · NICE CG154 / RCOG GTG 21