Combined HRT (body-identical oestrogen + micronised progesterone)
Estradiol with progesterone
Brand names: Bijuve
Adult dose
Dose: 1 capsule (estradiol 1mg / progesterone 100mg) OD
Route: Oral
Frequency: OD
Clinical pearls
- First UK-licensed combined HRT with body-identical oestradiol + micronised progesterone
- Continuous combined regimen — for women ≥1 year postmenopause
- Take at bedtime to mitigate progesterone-related drowsiness
- British Menopause Society endorses body-identical preparations
Contraindications
- Standard HRT contraindications
- Porphyria
- Severe peanut/soya allergy (excipient)
Side effects
- Breast tenderness
- Bleeding
- Headache
- Drowsiness (progesterone effect)
- VTE (oral oestrogen route)
Interactions
- CYP3A4 inducers
Monitoring
- BP
- Bleeding pattern
- Breast awareness
Reference: BNF; NICE NG23; British Menopause Society; SmPC; https://bnf.nice.org.uk/drugs/estradiol-with-progesterone/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Endotracheal Tube Depth and Tidal Volume Calculator · Airway Management
- TBSA — Total Body Surface Area Burned (Rule of Nines) · Formula
- Ideal & Adjusted Body Weight · Body Composition
- Relative Fat Mass (RFM) Calculator · Obesity
- Body Mass Index (BMI) · Anthropometry
- Body Surface Area (Mosteller) · Anthropometry
Pathways
- Spinal Anaesthesia Hypotension Management · AAGBI; ASA
- Pre-Eclampsia / Eclampsia in ED · NICE NG133; RCOG Green-top 10A
- Suspected Ectopic Pregnancy · NICE NG126; RCOG Green-top 21
- Polycystic Ovary Syndrome (PCOS) · International PCOS Guideline 2023; NICE CKS
- Pre-eclampsia Management · NICE NG133 2019
- Ectopic Pregnancy · NICE CG154 / RCOG GTG 21