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Topical imidazole antifungal

Tioconazole

Brand names: Trosyl

Tioconazole is a topical imidazole antifungal used to treat vulvovaginal candidiasis and, in other formulations, fungal nail infection.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It inhibits fungal cytochrome P450-dependent synthesis of ergosterol, disrupting the fungal cell membrane and producing a fungistatic to fungicidal effect against Candida species.

Prescribing in practice

  • Confirm the diagnosis of candidiasis and arrange review if symptoms persist or recur, as recurrent or treatment-resistant symptoms may indicate another cause.
  • Oil-based vaginal products can damage latex condoms and diaphragms, reducing their reliability.
  • Local irritation, burning, or itching at the application site can occur.

Monitoring

No laboratory monitoring is required; review if symptoms do not settle or frequently recur.

Counselling the patient

  • Use the vaginal preparation as directed, usually at bedtime.
  • Avoid relying on latex condoms or diaphragms while using oil-based vaginal products.
  • Seek review if symptoms persist, worsen, or keep coming back.

Evidence & guidelines

An established topical azole for vulvovaginal candidiasis consistent with current prescribing references.

Reference: NICE CKS; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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