Skip to content
ClinCalc Pro
Menu
Calculators Drugs Pathways AI Dx Donate Get the App
Topical Antibiotic Dressing

Framycetin Sulfate Gauze (Sofra-Tulle)

Brand names: Sofra-Tulle

An aminoglycoside antibiotic impregnated into a paraffin tulle dressing, applied topically to infected or potentially infected wounds, burns and skin-graft donor sites.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

Framycetin binds the bacterial 30S ribosomal subunit to inhibit protein synthesis, giving bactericidal activity against many Gram-negative and some Gram-positive organisms.

Prescribing in practice

  • Application to large or extensively damaged areas risks systemic absorption with ototoxicity and nephrotoxicity, so use should be limited and avoided on extensive burns or broken skin where absorption is high.
  • Cross-sensitivity with other aminoglycosides means it should be avoided in known aminoglycoside hypersensitivity.
  • Prolonged or widespread use encourages contact sensitisation and bacterial resistance and should be limited in duration.

Monitoring

Monitor the wound for response and local hypersensitivity; consider absorption-related risks if used on extensive or heavily exuding areas.

Counselling the patient

  • The medicated dressing helps prevent or treat wound infection.
  • Tell staff if you have had reactions to gentamicin or similar antibiotics.
  • Report any new rash or irritation around the dressing.

Evidence & guidelines

Framycetin-impregnated tulle is a long-established topical antibacterial dressing, with caution advised against use over large areas because of aminoglycoside absorption risks.

Reference: British Burns Association (BBA) Wound Care Guidelines; Confirm identity and dosing against the manufacturer SPC (eMC) and NICE. Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

Calculators