Ambroxol

How it works

It reduces sputum viscosity and stimulates surfactant production and ciliary activity, promoting mobilisation and expectoration of mucus.

Prescribing in practice

• Rare serious cutaneous reactions have been reported, so advise patients to stop and seek help if a rash or mucosal lesions develop.
• It is intended for symptomatic relief and does not treat the underlying cause of secretions.
• Caution is advised in patients with peptic ulcer disease given its gastrointestinal effects.

Monitoring

Review symptomatic benefit and monitor for skin or hypersensitivity reactions.

Counselling the patient

• Stop and seek medical advice if you develop a skin rash or blistering.
• Maintain adequate fluid intake to help loosen secretions.

Evidence & guidelines

MHRA has highlighted rare severe skin reactions with ambroxol-containing products; benefit otherwise rests on symptomatic mucolytic use.