CDK4/6 inhibitor
Abemaciclib [Specialist drug]
Brand names: Verzenios
Adult dose
Dose: Specialist (typically 150 mg BD with endocrine therapy; 200 mg BD monotherapy)
Route: Oral
Frequency: Per SACT/SmPC
Clinical pearls
- Refer to BNF/SmPC and SACT protocol; do not initiate outside oncology MDT
- Loperamide on hand for diarrhoea
Contraindications
- Severe hepatic impairment (per SmPC)
Side effects
- Diarrhoea (often early/severe)
- Neutropenia
- Fatigue
- VTE
- ILD
Interactions
- Strong CYP3A inhibitors/inducers
- Grapefruit juice
Monitoring
- FBC, LFTs
- VTE/ILD symptoms
Reference: BNF; NICE TA563/TA810; ESMO; SmPC Verzenios. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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