CDK4/6 inhibitor
Palbociclib (Specialist drug)
Brand names: Ibrance
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: OD x 21 days q28
Clinical pearls
- HR+ HER2- advanced breast cancer with endocrine therapy
- FBC every 2 weeks for first 2 cycles, then before each cycle
Contraindications
- Concurrent strong CYP3A4 inducers
- Severe hepatic impairment
Side effects
- Severe neutropenia (most common dose-limiting AE)
- Pulmonary embolism / VTE
- Pneumonitis
- Stomatitis
- Hepatotoxicity
Interactions
- Strong CYP3A4 modulators
- Drugs raising gastric pH
Monitoring
- FBC
- LFTs
- Pulmonary symptoms
Reference: BNF; NICE TA495; SmPC; https://bnf.nice.org.uk/drugs/palbociclib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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