L-asparaginase
Crisantaspase (Specialist drug)
Brand names: Erwinase
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IM/IV
Frequency: per protocol
Clinical pearls
- ALL — for patients hypersensitive to E. coli asparaginase
Contraindications
- Pancreatitis
- Severe hepatic impairment
- Bleeding disorder
Side effects
- Hypersensitivity (anaphylaxis)
- Pancreatitis
- Coagulopathy
- Hyperglycaemia
- Hepatotoxicity
Interactions
- Methotrexate (antagonism)
- Vincristine (toxicity)
Monitoring
- Coagulation
- Glucose
- Amylase/lipase
- LFTs
Reference: BNF; https://bnf.nice.org.uk/drugs/crisantaspase-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Vancomycin Dosing Calculator · Drug Dosing
- Phenytoin Correction for Albumin / Renal Failure · Drug Dosing
- Local Anaesthetic Maximum Dose Calculator · Drug Dosing
- Tisdale Risk Score for QT Prolongation · Arrhythmia
- Bazett Corrected QT Interval (QTc) Calculator · Arrhythmia
- DAPT Score for Dual Antiplatelet Therapy Duration · Antiplatelet Therapy
Pathways
- Acute Myeloid Leukaemia Presentation · BSH; NICE — NG146
- Tumour Lysis Syndrome · Cairo-Bishop; BSH; NICE — Best Practice
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158