Anti-CCR4 monoclonal antibody
Mogamulizumab (Specialist drug)
Brand names: Poteligeo
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV
Frequency: weekly then q2w
Clinical pearls
- Mycosis fungoides, Sézary syndrome; specialist haem-onc
Contraindications
- Hypersensitivity
Side effects
- Severe skin reactions (rash, SJS/TEN)
- Infusion reactions
- Cytopenias
- Hepatotoxicity
- Immune-mediated AEs (similar to checkpoint inhibitors)
Interactions
- Live vaccines
Monitoring
- FBC
- LFTs
- Skin
- Infection signs
Reference: BNF; NICE TA577; SmPC; https://bnf.nice.org.uk/drugs/mogamulizumab-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Vancomycin Dosing Calculator · Drug Dosing
- Phenytoin Correction for Albumin / Renal Failure · Drug Dosing
- Local Anaesthetic Maximum Dose Calculator · Drug Dosing
- Tisdale Risk Score for QT Prolongation · Arrhythmia
- Bazett Corrected QT Interval (QTc) Calculator · Arrhythmia
- DAPT Score for Dual Antiplatelet Therapy Duration · Antiplatelet Therapy
Pathways
- Acute Myeloid Leukaemia Presentation · BSH; NICE — NG146
- Tumour Lysis Syndrome · Cairo-Bishop; BSH; NICE — Best Practice
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158