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Non-acidic NSAID prodrug

Nabumetone

Brand names: Relifex

Adult dose

Dose: 1g at night, increase to 1g at night + 0.5–1g morning if needed

Route: PO

Frequency: OD-BD

Clinical pearls

OA, RA
Lower acute GI risk than non-selective NSAIDs (still significant)

Contraindications

Active GI bleeding/ulcer
Severe heart failure
Severe renal/hepatic impairment
Aspirin/NSAID hypersensitivity
3rd trimester pregnancy

Side effects

GI upset/bleeding
Renal impairment
Cardiovascular events
Headache

Interactions

Anticoagulants/antiplatelets
ACEi/ARB
Lithium
Methotrexate

Reference: BNF; NICE NG100; https://bnf.nice.org.uk/drugs/nabumetone/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

Pathways