Type II anti-CD20 monoclonal antibody
Obinutuzumab (Specialist drug)
Brand names: Gazyvaro
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV
Frequency: per protocol
Clinical pearls
- CLL, follicular lymphoma; specialist haem-onc
- Screen HBV before starting; pre-medicate with steroid + paracetamol + antihistamine
Contraindications
- Hypersensitivity to murine proteins
- Active severe infection
Side effects
- Severe infusion reactions (esp. cycle 1 — pre-medicate)
- Tumour lysis syndrome
- Cytopenias
- HBV reactivation
- PML (rare)
Interactions
- Live vaccines
Monitoring
- FBC
- LFTs
- HBsAg
- Tumour lysis screen
Reference: BNF; NICE TA343/TA513; SmPC; https://bnf.nice.org.uk/drugs/obinutuzumab-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Vancomycin Dosing Calculator · Drug Dosing
- Phenytoin Correction for Albumin / Renal Failure · Drug Dosing
- Local Anaesthetic Maximum Dose Calculator · Drug Dosing
- Tisdale Risk Score for QT Prolongation · Arrhythmia
- SCORE2-Diabetes 10-Year CVD Risk in Type 2 Diabetes · Cardiovascular Risk
- Bazett Corrected QT Interval (QTc) Calculator · Arrhythmia
Pathways
- Acute Myeloid Leukaemia Presentation · BSH; NICE — NG146
- Tumour Lysis Syndrome · Cairo-Bishop; BSH; NICE — Best Practice
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158