Menu

Calculators Drugs Pathways AI Dx Donate Get the App

NSAID (prodrug)

Sulindac

Brand names: Clinoril

Adult dose

Dose: 100–200mg PO BD

Route: PO

Frequency: BD

Clinical pearls

Rheumatic disease — short-term
Lower renal effects than other NSAIDs but more hepatic SJS signal

Contraindications

Active peptic ulcer/GI bleed
Severe HF
Severe renal/hepatic impairment
Pregnancy (3rd trimester)
NSAID-induced asthma
Aspirin allergy

Side effects

GI bleeding/ulceration
Hepatotoxicity
Renal impairment
Cardiovascular events
Stevens-Johnson syndrome (rare)
Headache

Interactions

Anticoagulants
Methotrexate
Lithium
Other NSAIDs
ACEi/ARB

Monitoring

U&E
LFTs
BP
FBC

Reference: BNF; NICE; https://bnf.nice.org.uk/drugs/sulindac/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

Pathways