Dual IDH1/2 inhibitor
Vorasidenib (Specialist drug)
Brand names: Voranigo
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: OD
Clinical pearls
- Grade 2 IDH-mutant astrocytoma / oligodendroglioma after surgery
- Specialist neuro-oncology
Contraindications
- Severe hepatic impairment
- Pregnancy
- Hypersensitivity
Side effects
- Hepatotoxicity
- Fatigue
- Headache
- Nausea
- Seizures
- QT prolongation
Interactions
- Strong CYP3A4 modulators
- QT-prolonging drugs
Monitoring
- LFTs
- ECG
Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/vorasidenib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Vancomycin Dosing Calculator · Drug Dosing
- Phenytoin Correction for Albumin / Renal Failure · Drug Dosing
- Local Anaesthetic Maximum Dose Calculator · Drug Dosing
- DAPT Score · Coronary Artery Disease
- Tisdale Risk Score for QT Prolongation · Arrhythmia
- PRECISE-DAPT Score for Bleeding on DAPT · Coronary Artery Disease
Pathways
- Acute Myeloid Leukaemia Presentation · BSH; NICE — NG146
- Tumour Lysis Syndrome · Cairo-Bishop; BSH; NICE — Best Practice
- Acute Stroke / TIA Assessment · NICE NG128; RCP Stroke Guidelines 2023
- Status Epilepticus (Adults) · NICE CG137; ESEM guidelines; RCP Neurology Guidelines
- Suspected Subarachnoid Haemorrhage · NICE NG228; RCEM 2023; AHA/ASA 2023
- Adult Head Injury · NICE NG232 (2023)