Neurology
Myasthenic Crisis
Respiratory failure in myasthenia gravis — distinguish from cholinergic crisis, IVIG / PLEX, ITU support, identify trigger.
Source: ABN; AAN consensus
Step 1 of ~3
info
Recognise
Acute respiratory failure or severe bulbar weakness in known/suspected myasthenia gravis (MG). Triggers: infection (most common), surgery, drugs (aminoglycosides, fluoroquinolones, beta-blockers, magnesium, ICI, neuromuscular blockers), pregnancy/postpartum, thymoma, abrupt steroid initiation/withdrawal, stress.
• Distinguish from cholinergic crisis: excessive pyridostigmine causes weakness + SLUDGE (Salivation, Lacrimation, Urination, Defecation, GI cramps, Emesis), miosis, fasciculations.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
Pathways
- Acute Stroke / TIA Assessment · NICE NG128; RCP Stroke Guidelines 2023
- Status Epilepticus (Adults) · NICE CG137; ESEM guidelines; RCP Neurology Guidelines
- Suspected Subarachnoid Haemorrhage · NICE NG228; RCEM 2023; AHA/ASA 2023
- Adult Head Injury · NICE NG232 (2023)
- Bell's Palsy / Facial Nerve Palsy · ENT UK 2017; AAN
- Vertigo Workup · ENT UK; NICE CKS
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