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cardiology genetics

Long QT Syndrome (Schwartz Score)

Estimates probability of congenital Long QT Syndrome using Schwartz-Moss criteria. Guides genetic testing, beta-blocker therapy, and ICD consideration.

Score interpretation

Low probability LQTS (<=1 point)

→ LQTS unlikely; check QTc-prolonging medications; genetic testing if clinical suspicion remains; family history review

Intermediate probability (2-3 points)

→ Electrophysiology and genetics referral; genetic testing (KCNQ1, KCNH2, SCN5A); exercise ECG; avoid QT-prolonging drugs; check crediblemeds.org

High probability LQTS (>=4 points)

→ Beta-blocker (nadolol or propranolol) — first-line; avoid QT-prolonging drugs; electrolyte correction; genetic testing mandatory; family screening; ICD for high-risk patients (prior VF, breakthrough symptoms on beta-blockers)

Interpretation bands for the LQTS Schwartz Score. Apply clinical judgement and local guidance.

References

Related

Curated clinical cross-links plus same-class fallbacks.

Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.