endocrinology

Cushing Syndrome Probability Score

Guidance on whom to test for Cushing's syndrome and which first-line tests to use. There is no validated points score — the page's tally was not a published method.

Result

There is no validated points score for the probability of Cushing's syndrome. Endocrine Society 2008 and the 2021 Cushing's consensus: first exclude exogenous glucocorticoids (including inhaled, topical and injected); test people with multiple, progressive features — especially those that best discriminate (easy bruising, facial plethora, proximal myopathy, reddish-purple striae wider than 1 cm) — features unusual for age (e.g. osteoporosis or hypertension in young people), an adrenal incidentaloma, and children with a falling height percentile and rising weight. First-line tests: late-night salivary cortisol (2 samples), overnight dexamethasone suppression test (Adults: dexamethasone 1 mg. Children: use a children's formulary.) or 24-hour urinary free cortisol (2 collections); refer abnormal results to endocrinology.

References

Curated clinical cross-links plus same-class fallbacks.

Calculators

Drugs

Pathways

Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.

References

Related