endocrinology
Cushing Syndrome Probability Score
Estimates clinical likelihood of Cushing syndrome to guide biochemical testing (24h UFC, LNSC, LDDST).
Score interpretation
Low clinical suspicion for Cushing
→ Cushing unlikely if < 2 criteria; address other causes of features; no immediate testing
Moderate suspicion
→ Biochemical testing: 24h urinary free cortisol, late-night salivary cortisol, 1mg LDDST; endocrinology referral
High clinical suspicion
→ Strong Cushing suspicion; all three confirmatory tests; CT adrenals or pituitary MRI; endocrinology urgently
Interpretation bands for the Cushing Score. Apply clinical judgement and local guidance.
References
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Drugs
- Ketoconazole (Adrenal Indication) · Adrenal Steroidogenesis Inhibitor (Antifungal with Adrenal Suppressing Properties)
- Metyrapone · Adrenal Steroidogenesis Inhibitor
- Aciclovir 800mg Tablets (Ramsay Hunt Syndrome / Herpes Zoster Oticus) · Antiviral — nucleoside analogue (herpes zoster treatment)
- Pramipexole (Restless Legs Syndrome — Elderly) · Dopamine Agonist (D2/D3 Receptor)
- Tetrabenazine · VMAT2 Inhibitor — Hyperkinetic Movement Disorders
- Nusinersen · Rare Neurological Disorders
Pathways
- Diabetic Ketoacidosis (DKA) · JBDS 2013 / Joint British Diabetes Societies; NICE NG17
- Adult Hypoglycaemia (Treated Diabetes) · JBDS-IP (2023): Hospital Management of Hypoglycaemia
- Adrenal Crisis · Society for Endocrinology Emergency Guidance (2024)
- Type 2 Diabetes Management · NICE NG28 2022
- Hyperthyroidism Management · BTA / ETA 2018
- Adrenal Insufficiency · Society of Endocrinology / ESE 2016
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.