Rh(D) Immune Globulin Dosage for Maternal-Fetal Haemorrhage
Calculates appropriate dose of Rh(D) immune globulin (anti-D) after maternal-fetal haemorrhage in Rh(D)-negative women. Based on Kleihauer-Betke test result. Prevents Rh sensitisation.
Score interpretation
Fetal-maternal haemorrhage <3 mL estimated fetal red blood cells
→ Standard prophylactic anti-D: 300 mcg IM (or 1,500 IU); administer within 72 hours of sensitising event; repeat Kleihauer in 48h to confirm adequate coverage; document in maternity notes
Significant fetal-maternal haemorrhage — calculate dose based on KB result
→ Calculate volume = (% fetal cells × maternal blood volume) ÷ 100; administer 300 mcg anti-D per 15 mL fetal whole blood (some guidelines per 30 mL); give IM in divided doses (max 1,500 mcg per site); repeat KB at 48–72h to confirm clearance; haematology involvement for large FMH
Interpretation bands for the Anti-D Dosage. Apply clinical judgement and local guidance.
References
- RCOG Green-top Guideline No. 22: The Use of Anti-D Immunoglobulin for Rhesus D Prophylaxis. 2011.
Related
Curated clinical cross-links plus same-class fallbacks.
- Rituximab (Haematology) · Anti-CD20 Monoclonal Antibody
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- Pembrolizumab · Anti-PD-1 monoclonal antibody (immune checkpoint inhibitor)
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.