respiratory critical-care emergency-medicine
ROX Index (Risk of Intubation on HFNC)
Predicts failure of high-flow nasal cannula (HFNC) oxygen therapy and need for intubation in acute hypoxaemic respiratory failure.
Score interpretation
HFNC likely to succeed
→ Continue HFNC; reassess at 2h, 6h, 12h
Borderline — monitor closely
→ Increase vigilance; prepare for intubation if worsening
High risk of HFNC failure
→ Prepare for early intubation; anaesthetics review
Interpretation bands for the ROX Index. Apply clinical judgement and local guidance.
References
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Drugs
- Palivizumab · RSV Prophylaxis — Monthly Monoclonal Antibody (High-Risk Infants)
- Hydroxocobalamin (High-Dose — Cyanide Antidote) · Cyanide Antidote (Vitamin B12 Precursor at High Dose)
- Doxapram hydrochloride · Respiratory stimulant
- Dobutamine (Acute HF / Stress Echo) · Inotrope / Acute Heart Failure
- Milrinone · Inodilator / Acute Heart Failure
- Vericiguat · Heart Failure
Pathways
- Acute Asthma in Adults · BTS/SIGN British Guideline on Asthma 2019; NICE NG80
- Pulmonary Embolism Assessment · NICE NG158; ESC 2019 PE Guidelines
- Acute Exacerbation of COPD (AECOPD) · NICE NG115; GOLD 2024
- Spontaneous Pneumothorax (Adult) · BTS Pleural Disease 2023
- Atypical Pneumonia (Legionella / Mycoplasma / Chlamydophila) · BTS 2023; IDSA
- COPD Exacerbation Management · NICE NG115 / GOLD 2024
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.