Antimuscarinic
Glycopyrronium bromide
Brand names: Robinul, Sialanar, Cuvposa
Adult dose
Dose: IM/IV pre-op antisialogogue: 200–400 micrograms. Excessive secretions in palliative care: 200–400 micrograms SC every 4–8h or 0.6–1.2mg/24h CSCI. Hyperhidrosis (oral): 1mg PO BD-TDS
Route: IV/IM/SC/PO
Frequency: PRN/continuous
Clinical pearls
- Does not cross BBB — preferred over hyoscine hydrobromide for secretions in palliative care (less sedation/confusion)
- Drying of saliva/respiratory secretions
Contraindications
- Closed-angle glaucoma
- GI obstruction
- Myasthenia gravis
- Severe ulcerative colitis
Side effects
- Dry mouth
- Constipation
- Urinary retention
- Tachycardia
- Reduced sweating
Interactions
- Other antimuscarinics
- Antipsychotics
- TCAs
Monitoring
- Symptoms
- Urinary output
Reference: BNF; SPC palliative; https://bnf.nice.org.uk/drugs/glycopyrronium-bromide/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs