Antimuscarinic
Hyoscine hydrobromide
Brand names: Joy-Rides, Kwells, Scopoderm
Adult dose
Dose: Motion sickness: 150–300 micrograms PO 30 min before journey, repeat every 6h (max 900 micrograms/24h). Patch (Scopoderm): 1.5mg patch every 72h. Palliative secretions: 400 micrograms SC every 4h or 1.2–2.4mg/24h CSCI
Route: PO/SC/Transdermal
Frequency: PRN
Clinical pearls
- Crosses BBB — more sedating/confusion-prone than hyoscine butylbromide; glycopyrronium often preferred for secretions in elderly
- Motion sickness, palliative secretions, hypersalivation
Contraindications
- Closed-angle glaucoma
- Myasthenia gravis
- Paralytic ileus
- Severe ulcerative colitis
Side effects
- Drowsiness (crosses BBB)
- Confusion in elderly
- Dry mouth
- Urinary retention
- Tachycardia
Interactions
- Other antimuscarinics
- CNS depressants
Reference: BNF; Palliative care formulary; https://bnf.nice.org.uk/drugs/hyoscine-hydrobromide/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.