Dihydropyridine calcium-channel blocker
Lercanidipine hydrochloride
Brand names: Zanidip
Adult dose
Dose: 10mg OD; max 20mg OD
Route: PO
Frequency: OD
Clinical pearls
- Hypertension; less ankle oedema than amlodipine
- Take ≥15 min before food
Contraindications
- Cardiogenic shock
- Unstable angina
- Recent MI
- Severe aortic stenosis
- Severe hepatic/renal impairment
- Concurrent strong CYP3A4 inhibitors
Side effects
- Ankle oedema (lower than amlodipine)
- Headache
- Flushing
- Palpitations
Interactions
- Grapefruit juice
- Strong CYP3A4 modulators
- β-blockers
- Other antihypertensives
Monitoring
- BP
Reference: BNF; NICE NG136; https://bnf.nice.org.uk/drugs/lercanidipine-hydrochloride/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Drugs
Pathways
- Acute Heart Failure · ESC 2021 Heart Failure Guidelines; NICE NG106
- NSTEMI / Unstable Angina · ESC 2020 NSTEMI Guidelines; NICE NG185
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines