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Dihydropyridine calcium-channel blocker

Nicardipine hydrochloride

Brand names: Cardene

Adult dose

Dose: PO 20mg TDS, increase to 30mg TDS. IV (hypertensive emergency): 5–15 mg/h infusion
Route: PO/IV
Frequency: TDS or infusion

Clinical pearls

  • IV nicardipine alternative to labetalol/clevidipine for hypertensive emergency
  • Useful for blood pressure control in subarachnoid haemorrhage

Contraindications

  • Cardiogenic shock
  • Unstable angina
  • Recent MI
  • Severe aortic stenosis
  • Pregnancy/breastfeeding

Side effects

  • Headache
  • Flushing
  • Tachycardia
  • Ankle oedema

Interactions

  • Strong CYP3A4 modulators
  • Other antihypertensives

Monitoring

  • BP
  • HR

Reference: BNF; ESC; https://bnf.nice.org.uk/drugs/nicardipine-hydrochloride/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.