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Non-selective β-blocker

Nadolol

Brand names: Corgard

Adult dose

Dose: 40mg OD initially, max 240mg/day. Migraine prophylaxis: 40–160mg/day
Route: PO
Frequency: OD

Clinical pearls

  • Long-acting non-selective β-blocker; migraine prophylaxis

Contraindications

  • Asthma
  • Severe bradycardia
  • 2nd/3rd degree AV block
  • Cardiogenic shock
  • Severe heart failure

Side effects

  • Bradycardia
  • Bronchospasm
  • Cold extremities
  • Fatigue
  • Sleep disturbance

Interactions

  • Verapamil/diltiazem
  • Other antihypertensives
  • Insulin/sulfonylureas (mask hypos)

Monitoring

  • BP
  • HR

Reference: BNF; NICE NG136; https://bnf.nice.org.uk/drugs/nadolol/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.