Conestat alfa

How it works

It is a recombinant form of human C1-esterase inhibitor that replaces the deficient or dysfunctional protein, restoring regulation of the complement and contact (kallikrein-kinin) systems and reducing bradykinin-mediated swelling.

Prescribing in practice

• It is produced in the milk of transgenic rabbits and is contraindicated in patients with known or suspected allergy to rabbits or rabbit-derived products.
• It is administered by slow intravenous injection for the treatment of acute attacks.
• Hypersensitivity reactions can occur and may be difficult to distinguish from angioedema, so it should be given where appropriate management is available, per the SPC.

Monitoring

Monitor for resolution of the acute attack and for signs of hypersensitivity during and after administration.

Counselling the patient

• This medicine treats sudden swelling attacks of hereditary angioedema.
• Tell your clinician if you are allergic to rabbits, as it is derived from rabbit milk.
• Seek urgent help if you develop signs of an allergic reaction such as rash, wheeze or worsening swelling.

Evidence & guidelines

Conestat alfa is supported by randomised controlled trials demonstrating reduced time to relief of acute hereditary angioedema attacks.