Mannitol

No UK SPC posology was available in the bundle; dose taken from US labelling (OSMITROL, DailyMed) - verify against the UK SPC. Total dosage, concentration and rate of administration depend on the age, weight and condition of the patient, including fluid requirement, electrolyte balance, serum osmolality, urinary output and concomitant therapy; the labelled regimen is described as a general guide only. Evaluate renal, cardiac and pulmonary status and correct fluid and electrolyte imbalances before administration. For intraocular pressure, 1.5 to 2 g/kg corresponds to 7.5 to 10 mL/kg of a 20% w/v solution or 10 to 13 mL/kg of a 15% w/v solution; when used preoperatively, administer 60 to 90 minutes before surgery. Monitor fluid and electrolytes, serum osmolarity and renal, cardiac and pulmonary function during and after infusion; discontinue if renal, cardiac or pulmonary status worsens or CNS toxicity develops. Use administration sets with a final in-line filter because of the potential for crystals to form. Do not administer simultaneously with blood products through the same set. Paediatric use: approved for reduction of intracranial and intraocular pressure, but studies have not defined the optimal paediatric dose; children under two years, particularly preterm and term neonates, may be at higher risk of fluid and electrolyte abnormalities - verify paediatric dosing against a children's formulary.