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Oral rehydration salts Pregnancy: SPC 4.6: not contraindicated in pregnancy or lactation, but should be used on medical advice. There are limited data in pregnant and in breast-feeding women and no conclusions can be drawn on safety, so it should be used only if the potential benefits to the mother outweigh the potential risks, including those to the fetus or breastfed child.

Potassium chloride with rice powder, sodium chloride and sodium citrate

Brand names: Dioralyte Relief

Used in: Hyponatraemia

This is an oral rehydration salts preparation containing potassium chloride, rice powder, sodium chloride and sodium citrate, used to treat and prevent dehydration from acute diarrhoea.

Auto-extracted from the source labelling — not yet independently clinician-verified. These values were distilled from the UK SPC (or the US label where noted) but have not had a clinician sign-off. Confirm against the current SmPC before prescribing.

Adult dose

Dose: One sachet, dissolved in 200 ml of drinking water, after every loose motion
Route: Oral (for oral administration only)
Frequency: After every loose motion
Max: Maximum of 5 sachets per day, for 3-4 days
SPC 4.2 gives this regimen for 'Adults and children'. Method of administration: pour the contents of one sachet into a large glass, add 200 ml of drinking water, mix well until the liquid has a milky appearance and drink the whole glassful; ensure no solid remains at the bottom of the glass and do not use extra water to rinse it out. The solution should be made up immediately before use, and must not be reconstituted in any diluent other than water; each sachet should always be dissolved in 200 ml of water. For infants, and where drinking water is not available, the water should be freshly boiled and cooled. PAEDIATRIC (non per-kg-in-mg, so not captured as a structured paediatric dose): SPC 4.2 states that for infants from 3 months to one year, under medical advice, in the event of diarrhoea and depending on the extent of dehydration (loss of weight assessed at less than 10%), 150 to 200 ml/kg/24 hours of the preparation may be given - half the volume during the first 8 hours and the other half during the next 16 hours; where vomiting accompanies the diarrhoea the amount administered can be divided up (5 to 10 ml every 5 minutes) and gradually increased until the infant can drink normally. SPC 4.4: must not be given to infants under 3 months; infants aged 3 months to 1 year only under medical advice; infants under 2 years with diarrhoea should be seen by a physician as soon as possible; if diarrhoea persists unremittingly for longer than 36 hours the patient should be reassessed. Verify all paediatric dosing against a children's formulary. No specific precautions are necessary in the elderly, but take care where normal electrolyte balance may be disturbed (e.g. severe vomiting or diarrhoea). Not for self-treatment by patients on low potassium or low sodium diets - such use should be supervised by a physician. Each sachet contains 190 mg sodium, equivalent to 10% of the WHO recommended maximum daily dietary intake of 2 g of sodium for an adult. Product fetched: Dioralyte Relief Blackcurrant Sachets GSL.

Dose adjustments

Renal

SPC 4.3 states treatment may be inappropriate in cases of severe renal impairment. No numeric dose adjustment is stated.

Dose auto-extracted from UK Summary of Product Characteristics (SPC) via the eMC; US FDA prescribing information (openFDA / DailyMed) — cross-check; US labelling may differ from UK — not yet clinician-verified. Always confirm against the product SmPC and your local formulary before prescribing.

Contraindications

  • Hypersensitivity to the active substances or to any of the excipients
  • Phenylketonuria (this blackcurrant formulation should not be used)
  • May be inappropriate in intestinal obstruction requiring surgical intervention
  • May be inappropriate in cases of severe renal or hepatic impairment

Side effects

  • Hypersensitivity (frequency not known) - the only adverse reaction listed in SPC 4.8

Interactions

  • SPC 4.5: none known

Clinical monograph

How it works

Glucose or rice-derived carbohydrate drives co-transport of sodium and water across the intestinal mucosa, while the salts replace electrolyte losses and citrate corrects the acidosis of diarrhoeal illness.

Prescribing in practice

  • Reconstitute only with the recommended volume of clean water and never add extra salt or sugar, as incorrect concentration can cause hypernatraemia, particularly in infants.
  • It is not a substitute for intravenous fluids in severe dehydration, shock or persistent vomiting, where parenteral resuscitation is required.
  • The potassium content warrants caution in renal impairment or where potassium excretion is reduced.

Monitoring

Monitor hydration status, urine output and, where dehydration is significant, serum electrolytes during rehydration.

Counselling the patient

  • Make up the solution exactly as directed with clean water and discard any unused reconstituted solution after the stated time.
  • Continue normal feeding and breastfeeding, and seek medical help if dehydration worsens or the person cannot keep fluids down.

Evidence & guidelines

Oral rehydration therapy is endorsed by the WHO as the mainstay of management for acute diarrhoeal dehydration, with rice-based formulations offering an alternative carbohydrate source.

Reference: NICE CG84; WHO; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. The structured dose values shown have been reviewed by a clinician. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.