Potassium chloride with rice powder, sodium chloride and sodium citrate
Brand names: Dioralyte Relief
This is an oral rehydration salts preparation containing potassium chloride, rice powder, sodium chloride and sodium citrate, used to treat and prevent dehydration from acute diarrhoea.
Adult dose
Dose adjustments
SPC 4.3 states treatment may be inappropriate in cases of severe renal impairment. No numeric dose adjustment is stated.
Dose auto-extracted from UK Summary of Product Characteristics (SPC) via the eMC; US FDA prescribing information (openFDA / DailyMed) — cross-check; US labelling may differ from UK — not yet clinician-verified. Always confirm against the product SmPC and your local formulary before prescribing.
Contraindications
- Hypersensitivity to the active substances or to any of the excipients
- Phenylketonuria (this blackcurrant formulation should not be used)
- May be inappropriate in intestinal obstruction requiring surgical intervention
- May be inappropriate in cases of severe renal or hepatic impairment
Side effects
- Hypersensitivity (frequency not known) - the only adverse reaction listed in SPC 4.8
Interactions
- SPC 4.5: none known
Clinical monograph
How it works
Glucose or rice-derived carbohydrate drives co-transport of sodium and water across the intestinal mucosa, while the salts replace electrolyte losses and citrate corrects the acidosis of diarrhoeal illness.
Prescribing in practice
- Reconstitute only with the recommended volume of clean water and never add extra salt or sugar, as incorrect concentration can cause hypernatraemia, particularly in infants.
- It is not a substitute for intravenous fluids in severe dehydration, shock or persistent vomiting, where parenteral resuscitation is required.
- The potassium content warrants caution in renal impairment or where potassium excretion is reduced.
Monitoring
Monitor hydration status, urine output and, where dehydration is significant, serum electrolytes during rehydration.
Counselling the patient
- Make up the solution exactly as directed with clean water and discard any unused reconstituted solution after the stated time.
- Continue normal feeding and breastfeeding, and seek medical help if dehydration worsens or the person cannot keep fluids down.
Evidence & guidelines
Oral rehydration therapy is endorsed by the WHO as the mainstay of management for acute diarrhoeal dehydration, with rice-based formulations offering an alternative carbohydrate source.
Reference: NICE CG84; WHO; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. The structured dose values shown have been reviewed by a clinician. Monograph status: clinician-reviewed (2026-07-04).
Related
Curated clinical cross-links plus same-class fallbacks.
- DOAC Score for Selecting Direct Oral Anticoagulant in Non-Valvular AF · Anticoagulation
- Corrected Sodium (Hyperglycaemia) · Electrolytes
- Hyponatraemia Cause Algorithm · Electrolyte Disorders
- Hyperkalaemia Management Algorithm · Electrolyte Disorders
- MELD-Na Score · Liver Disease
- MELD-Na Score for Liver Cirrhosis · Hepatology
- Lower Gastrointestinal Bleed · BSG 2019; NICE NG141
- Variceal Upper GI Bleed · BSG 2015; Baveno VII (2022)
- Spontaneous Bacterial Peritonitis (SBP) · BSG / EASL 2018
- Hepatorenal Syndrome · EASL 2018; ICA 2015
- Hepatic Encephalopathy · EASL 2014; West Haven criteria
- Clostridioides difficile Colitis · NICE NG199 (2021); IDSA/SHEA 2021