H1-antihistamine (theoclate salt)
Promethazine teoclate
Brand names: Avomine
Adult dose
Dose: Motion sickness: 25mg ON before travel. Hyperemesis gravidarum: 25mg ON
Route: PO
Frequency: ON
Clinical pearls
- Motion sickness, hyperemesis (1st-line per RCOG GTG-69 with cyclizine)
- Long-acting — once daily dosing
Contraindications
- Children <2
- Concurrent MAOI
Side effects
- Sedation
- Anticholinergic effects
- Paradoxical excitement (children)
Interactions
- CNS depressants
- MAOIs
Reference: BNF; RCOG GTG-69; https://bnf.nice.org.uk/drugs/promethazine-teoclate/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Pathways
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines
- Syncope Assessment · ESC 2018 Syncope Guidelines; NICE NG109
- Acute Chest Pain · NICE CG95; ESC 2023 ACS Guidelines