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Thiazide Diuretic

Bendroflumethiazide

Brand names: Bendroflumethiazide (generic), Centyl (less common)

Bendroflumethiazide is a thiazide diuretic used for hypertension.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It inhibits sodium-chloride reabsorption in the distal tubule, producing a mild diuresis and lowering blood pressure.

Prescribing in practice

  • It can cause hypokalaemia, hyponatraemia, raised urate (gout) and small rises in glucose and lipids — check electrolytes.
  • Current guidance prefers thiazide-like diuretics (e.g. indapamide) for hypertension.
  • Its effect is reduced at low eGFR.

Monitoring

Check U&E after initiation and periodically; monitor blood pressure.

Counselling the patient

  • Take it in the morning.
  • Report cramps, marked tiredness or dizziness.
  • It can trigger gout in susceptible people.

Evidence & guidelines

A thiazide diuretic for hypertension; thiazide-like agents are now generally preferred (NICE NG136).

Reference: NICE NG136; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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