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Antispasmodic (Direct-Acting)

Mebeverine Hydrochloride

Brand names: Colofac, Colofac MR

Mebeverine is an antispasmodic used to relieve the cramping abdominal pain and spasm of irritable bowel syndrome and related gastrointestinal disorders.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It is a direct relaxant of gastrointestinal smooth muscle, easing spasm without the systemic antimuscarinic effects seen with anticholinergic antispasmodics.

Prescribing in practice

  • Avoid in paralytic ileus.
  • It has few systemic effects, which makes it a useful option where anticholinergic burden is a concern.
  • It is usually taken before meals.

Monitoring

No specific laboratory monitoring is needed; review symptom control and reconsider the diagnosis if pain persists or alarm features develop.

Counselling the patient

  • Take this medicine before your meals.
  • It works on the gut to ease cramping pain and spasm.
  • Tell your doctor if your symptoms change or do not improve.

Evidence & guidelines

An established option for IBS-related abdominal pain in NICE guidance on irritable bowel syndrome.

Reference: NICE CG61 Irritable Bowel Syndrome; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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