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Proton pump inhibitor

Rabeprazole sodium

Brand names: Pariet

Adult dose

Dose: GORD/duodenal ulcer: 20mg PO OD for 4–8 weeks. H. pylori eradication: 20mg BD with antibiotics x7 days. Maintenance 10mg OD
Route: PO
Frequency: OD-BD

Clinical pearls

  • Acid-related disorders; lower CYP2C19 dependence than omeprazole
  • Review need for long-term PPI annually (NICE/MHRA)

Contraindications

  • Hypersensitivity
  • Concurrent rilpivirine

Side effects

  • GI upset
  • Headache
  • Hypomagnesaemia
  • B12 deficiency (long-term)
  • Increased fracture risk
  • C. difficile infection
  • Subacute cutaneous lupus erythematosus

Interactions

  • Clopidogrel (less than omeprazole)
  • Methotrexate
  • Digoxin
  • Iron

Monitoring

  • Magnesium (long-term)
  • Symptoms

Reference: BNF; NICE CG184; MHRA; https://bnf.nice.org.uk/drugs/rabeprazole-sodium/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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