siRNA targeting transthyretin (TTR)
Vutrisiran
Brand names: Amvuttra
Adult dose
Dose: 25mg SC every 3 months
Route: SC
Frequency: q3mo
Clinical pearls
- Hereditary transthyretin amyloidosis with polyneuropathy
- Vitamin A 2500 IU/day required; specialist amyloid
Contraindications
- Hypersensitivity
Side effects
- Vitamin A deficiency
- Arthralgia
- Dyspnoea
- Injection-site reactions
Monitoring
- Vitamin A
- Cardiac function
- Symptoms
Reference: BNF; NICE HST24; SmPC; https://bnf.nice.org.uk/drugs/vutrisiran/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Pathways
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO