Interferon gamma-1b

How it works

It augments phagocyte oxidative metabolism and macrophage function, enhancing the killing of intracellular pathogens.

Prescribing in practice

• Flu-like symptoms (fever, chills, myalgia, headache) are very common, especially early in treatment, and can be mitigated by bedtime dosing and antipyretics.
• Use with caution in patients with pre-existing cardiac disease or seizure disorders, which may be exacerbated.
• It can cause reversible neutropenia and hepatic enzyme elevation, particularly in younger children.

Monitoring

Monitor full blood count, renal and liver function periodically during therapy.

Counselling the patient

• Flu-like effects are common at first and often ease with continued treatment.
• Use the injection technique you have been taught and rotate injection sites.
• Store the product refrigerated and do not freeze or shake it.

Evidence & guidelines

Use in chronic granulomatous disease is supported by a landmark placebo-controlled trial demonstrating reduced serious infections (International CGD Cooperative Study).