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Vaccine

Meningococcal group B vaccine

Brand names: Bexsero, Trumenba

The meningococcal group B vaccine is a multicomponent protein-based vaccine providing active immunisation against invasive disease caused by Neisseria meningitidis serogroup B, given as part of the UK routine infant programme.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It contains recombinant meningococcal B surface proteins together with outer membrane vesicle antigens that elicit bactericidal antibodies against serogroup B strains expressing the relevant antigens.

Prescribing in practice

  • Fever is common after infant doses, and prophylactic paracetamol is recommended around vaccination to reduce its incidence and severity per UK guidance.
  • It is given as part of the routine infant schedule, and the recommended dosing course should be completed for optimal protection.
  • It targets serogroup B and does not replace meningococcal ACWY or other meningococcal immunisation where indicated.

Monitoring

Observe for immediate hypersensitivity after administration and monitor for post-vaccination fever in infants.

Counselling the patient

  • Fever is common after this vaccine in babies, and paracetamol is advised around the time of vaccination.
  • Complete all the recommended doses for the best protection.
  • Some redness or tenderness at the injection site is normal and settles.

Evidence & guidelines

UK guidance from the national immunisation programme recommends routine infant meningococcal B vaccination with prophylactic paracetamol to mitigate fever.

Reference: UK Green Book; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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