Netilmicin
Netilmicin is an aminoglycoside antibacterial used parenterally for serious Gram-negative infections, including some resistant to other aminoglycosides.
We found no UK product information (SmPC) for this medicine or presentation on the eMC or MHRA Products (checked October 2026). It may be unlicensed in the UK, imported, a medical device, or no longer marketed. ClinCalc Pro shows only doses it can trace to official product information, so none is shown — follow your specialist service or local guideline.
Clinical monograph
How it works
It binds to the bacterial 30S ribosomal subunit, causing misreading of the genetic code and inhibiting protein synthesis, giving a concentration-dependent bactericidal effect.
Prescribing in practice
- Like all aminoglycosides it carries a dose- and duration-related risk of ototoxicity and nephrotoxicity, so therapeutic drug monitoring and renal function checks are essential.
- Risk is increased in renal impairment, the elderly, with prolonged courses and with concurrent nephrotoxic or ototoxic drugs.
- It should be avoided in myasthenia gravis as aminoglycosides can impair neuromuscular transmission.
Monitoring
Monitor serum drug concentrations, renal function and auditory/vestibular function during treatment, especially with longer courses.
Counselling the patient
- Report any hearing loss, ringing in the ears, dizziness or reduced urine output.
- Tell the team about any kidney problems or other medicines you take.
Evidence & guidelines
The need for level and renal monitoring with aminoglycosides is standard practice supported by the SPC and current prescribing references.
Reference: UK AMR; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).
Related
Curated clinical cross-links plus same-class fallbacks.
- Centor / McIsaac Score for Strep Pharyngitis · Throat
- Acute Otitis Media — Antibiotic or Observation (AAP 2013) · Otitis Media
- Ideal Body Weight (Devine) · Anthropometry
- FeverPAIN Score for Strep Throat · Throat
- Jarisch-Herxheimer Reaction Severity Assessment · Treatment Reactions
- PID Diagnosis and Hospitalisation (CDC Criteria) · Gynaecological Infections
- Infective Endocarditis · ESC 2023 Infective Endocarditis Guidelines; NICE NG41
- Eczema Herpeticum · BAD; NICE CKS
- Suspected Bacterial Meningitis (Adult) · NICE NG240 (2024); NICE NG143 (paeds)
- Clostridioides difficile Colitis · NICE NG199 (2021); IDSA/SHEA 2021
- Returning Traveller — Fever · NaTHNaC; PHE; ESCMID 2018
- Malaria — Diagnosis & Management · PHE 2016; WHO 2023