Typhoid vaccine (inactivated)

eMC §4.2 (TYPHIM Vi Solution for Injection - the Vi capsular polysaccharide typhoid vaccine, which matches this inactivated-vaccine page). The 0.5 mL single dose applies to adults and children over 2 years of age. CHILDREN UNDER 2 YEARS: as with other polysaccharide vaccines, the antibody response may be inadequate in children under 2 years of age (the SPC gives no separate dose for this group). ELDERLY: as for adults and children over 2 years of age. §4.4: this vaccine protects against Salmonella typhi only and gives NO protection against Salmonella paratyphi A or B or against non-typhoidal Salmonellae. Before administration, the recipient or their guardian must be asked about personal history, current health status and any adverse event after previous immunisations; in subjects with a history of a serious or severe reaction within 48 hours of a previous injection of a vaccine containing similar components, the need for vaccination must be carefully considered following a risk-benefit assessment. Facilities for the management of anaphylaxis should always be available, and epinephrine injection (1:1000) must be immediately available. Syncope can occur following, or even before, vaccination, especially in adolescents, and may be accompanied by transient visual disturbance, paraesthesia and tonic-clonic limb movements during recovery - have procedures in place to avoid injury from faints. Administer with caution to subjects with thrombocytopenia or a bleeding disorder, since bleeding may occur after intramuscular administration. Vaccination may not result in protection in all recipients, and immunogenicity may be reduced by immunosuppressive treatment or immunodeficiency, in which case it is recommended to postpone vaccination until the end of the disease or treatment; nevertheless vaccination of subjects with chronic immunodeficiency such as HIV infection is recommended even if the antibody response might be limited. The product contains less than 1 mmol sodium (23 mg) per dose, i.e. is essentially sodium-free. Record the name and batch number of the administered product for traceability.