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Inactivated polysaccharide typhoid vaccine

Typhoid vaccine (inactivated)

Brand names: Typhim Vi, Typherix

An inactivated vaccine (Vi capsular polysaccharide injection) used to provide active immunisation against Salmonella Typhi for travellers to endemic areas and certain occupational groups.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

The purified Vi capsular polysaccharide antigen stimulates a T-cell-independent humoral antibody response against the typhoid bacterium, conferring partial protection.

Prescribing in practice

  • Protection is incomplete, so vaccinees must still be counselled on food, water and personal hygiene precautions; booster doses are needed for continued exposure.
  • Administer well in advance of travel to allow time for the immune response to develop.
  • It does not protect against paratyphoid fever or other gastrointestinal pathogens.

Monitoring

No routine laboratory monitoring is required; observe briefly after injection for immediate hypersensitivity reactions.

Counselling the patient

  • Keep maintaining strict food and water hygiene as the vaccine does not give complete protection.
  • A repeat dose is required before further travel if exposure continues.
  • Mild soreness at the injection site, headache or low-grade fever may occur.

Evidence & guidelines

Use is guided by UK national immunisation guidance (the Green Book) and current travel-health recommendations.

Reference: UKHSA Green Book Ch.33; Confirm identity and dosing against the manufacturer SPC (eMC) and NICE. Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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