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Macrolide Antibiotic — Bacterial Conjunctivitis / Trachoma / Blepharitis

Azithromycin 1.5% Eye Drops

Brand names: AzaSite, Azithrocin Eye

Azithromycin eye drops are a topical macrolide antibiotic used for bacterial conjunctivitis and for trachomatous (Chlamydia trachomatis) conjunctivitis.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It binds the bacterial 50S ribosomal subunit and inhibits protein synthesis, giving a bacteriostatic effect against susceptible organisms.

Prescribing in practice

  • It is not indicated for the deeper structures of the eye and should not be used to treat keratitis or intraocular infection.
  • Discontinue and reassess if hypersensitivity or worsening occurs, and reconsider the diagnosis if there is no improvement.
  • Avoid contact lens wear during active infection and treatment.

Monitoring

Monitor clinically for resolution of conjunctival signs and for any local hypersensitivity reaction.

Counselling the patient

  • Transient stinging, blurred vision or eye discomfort after instillation is common.
  • Do not wear contact lenses until the infection has cleared.
  • Complete the prescribed course even if the eye improves quickly.

Evidence & guidelines

Topical azithromycin is an established treatment for bacterial and trachomatous conjunctivitis as reflected in current prescribing references.

Reference: MHRA Drug Safety Update 2013 (Azithromycin QTc); WHO SAFE Strategy for Trachoma; SPC AzaSite; RCOphth Bacterial Conjunctivitis Guidelines; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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