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Potent Ophthalmic Corticosteroid — Uveitis / Post-Operative Inflammation

Difluprednate 0.05% Eye Drops

Brand names: Durezol

Difluprednate is a potent topical corticosteroid eye drop used to treat ocular inflammation and pain, including following eye surgery and in endogenous anterior uveitis.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

Difluprednate is a glucocorticoid that binds corticosteroid receptors to inhibit inflammatory mediators and reduce vascular permeability and leucocyte activity in ocular tissue.

Prescribing in practice

  • As a potent topical steroid it can raise intraocular pressure and promote cataract, and may delay healing or worsen and mask ocular infection, so it requires ophthalmic supervision.
  • It is contraindicated in untreated infective eye conditions, including herpes simplex (dendritic) keratitis and most acute purulent infections.
  • Prolonged courses should be tapered to reduce the risk of rebound inflammation.

Monitoring

Monitor intraocular pressure during therapy and review for signs of infection or lens opacity, especially with extended use.

Counselling the patient

  • Shake the bottle if instructed and use the drops exactly as prescribed.
  • Report any eye pain, reduced vision or increasing redness.
  • Keep your follow-up appointments so eye pressure can be checked.

Evidence & guidelines

Topical corticosteroids including difluprednate are used for postoperative ocular inflammation and uveitis, with prescribing guided by the SPC.

Reference: FDA Approval Durezol 2008; SPC Difluprednate 0.05%; Sheppard et al. Trans Am Ophthalmol Soc 2014; RCOphth Uveitis Management Guidelines; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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