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Prostaglandin analogue + β-blocker

Latanoprost with timolol

Brand names: Xalacom

Adult dose

Dose: 1 drop in affected eye(s) OD

Route: Topical (ophthalmic)

Frequency: OD

Clinical pearls

Open-angle glaucoma/ocular hypertension when monotherapy insufficient
Ask about asthma/COPD before prescribing — small but real systemic absorption

Contraindications

Asthma
Severe COPD
Severe bradycardia
Heart block
Hypersensitivity

Side effects

Conjunctival hyperaemia
Iris pigmentation
Bronchospasm (timolol systemic absorption)
Bradycardia

Interactions

Systemic β-blockers (additive)
CCBs

Monitoring

IOP
BP
HR

Reference: BNF; https://bnf.nice.org.uk/drugs/latanoprost-with-timolol/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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