Deflazacort

How it works

It binds glucocorticoid receptors to modulate gene expression, suppressing inflammation and immune responses.

Prescribing in practice

• Prolonged use causes adrenal suppression, so it must not be stopped abruptly and the dose should be tapered gradually; patients require sick-day guidance.
• Long-term corticosteroid use carries risks including growth suppression in children, osteoporosis, weight gain, hyperglycaemia and increased infection susceptibility.
• Live vaccines should generally be avoided during immunosuppressive doses, and exposure to chickenpox or measles in non-immune patients needs prompt assessment.

Monitoring

Monitor growth in children, weight, blood pressure, blood glucose and bone health during long-term treatment.

Counselling the patient

• Never stop this medicine suddenly; carry a steroid alert card and follow sick-day advice if unwell.
• Avoid contact with chickenpox or measles if you have not had them, and report any exposure.
• Report increased thirst, frequent infections or mood changes to your team.

Evidence & guidelines

Corticosteroids such as deflazacort are recommended to preserve muscle function in Duchenne muscular dystrophy.