Human Albumin Solution (Burns)

How it works

As the principal plasma protein, albumin exerts colloid oncotic pressure that helps retain administered fluid within the intravascular compartment, supporting circulating volume in patients with capillary leak.

Prescribing in practice

• Infuse with close haemodynamic monitoring, as rapid administration can precipitate circulatory overload and pulmonary oedema, particularly once capillary integrity is restored.
• Reserve colloid use in burns for the later resuscitation phase or where crystalloid resuscitation alone is failing, in line with local major-burns protocols.
• As a pooled human plasma derivative it carries the theoretical risks of any blood product and should be prescribed against current prescribing references and transfusion governance.

Monitoring

Monitor haemodynamic status, urine output, fluid balance and signs of circulatory overload throughout and after the infusion.

Counselling the patient

• Explain to the team that this is a blood-derived product given to support circulation during burns resuscitation.
• Document infusion against the burns fluid-balance chart and review the rate frequently.
• Report breathlessness or signs of fluid overload to the medical team promptly.

Evidence & guidelines

Burns resuscitation is guided by established protocols such as those informed by the Parkland approach, with colloid use individualised to the patient and local major-burns guidance.