Atypical antipsychotic
Lurasidone hydrochloride
Brand names: Latuda
Adult dose
Dose: 37mg PO OD with food (≥350 kcal); range 18.5–148mg/day
Route: PO
Frequency: OD
Clinical pearls
- Schizophrenia
- Take with substantial food for adequate absorption
Contraindications
- Concurrent strong CYP3A4 inhibitors/inducers
- Hypersensitivity
Side effects
- Akathisia
- EPSE
- Somnolence
- Nausea
- Hyperprolactinaemia
- Less weight/metabolic effect than other antipsychotics
Interactions
- Strong CYP3A4 modulators (avoid)
- CNS depressants
- QT-prolonging drugs
Monitoring
- BP
- Glucose/lipids
- Weight
- Prolactin
Reference: BNF; NICE NG178; Maudsley; https://bnf.nice.org.uk/drugs/lurasidone-hydrochloride/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Pathways
- Acute Behavioural Disturbance / Rapid Tranquillisation · RCEM 2022; RCPsych 2022; NICE NG10
- Self-Harm Presentation · NICE NG225 (2022)
- Capacity Assessment (Mental Capacity Act) · MCA 2005; Code of Practice
- Acute Psychosis Management · NICE CG178 2014
- Depression Management · NICE CG90 2022
- Lithium Therapy Monitoring · NICE CG185 / BNF