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ICS + LABA inhaler

Fluticasone with salmeterol

Brand names: Seretide, AirFluSal, Sereflo, Sirdupla

Adult dose

Dose: Asthma: 1 inhalation Seretide Accuhaler BD (50/100, 50/250, 50/500). MDI 2 puffs BD. COPD: Seretide 500 Accuhaler 1 inh BD
Route: Inhaled
Frequency: BD

Clinical pearls

  • Asthma uncontrolled on ICS; severe COPD with frequent exacerbations
  • Not a rescue inhaler

Contraindications

  • Hypersensitivity

Side effects

  • Tremor
  • Tachycardia
  • Hypokalaemia
  • Oral candidiasis
  • Pneumonia in COPD (ICS class effect)

Interactions

  • β-blockers
  • QT-prolonging drugs
  • Strong CYP3A4 inhibitors (ritonavir → Cushing's)

Monitoring

  • Asthma control
  • Inhaler technique
  • Pneumonia signs in COPD

Reference: BNF; BTS/SIGN; NICE NG115; https://bnf.nice.org.uk/drugs/fluticasone-with-salmeterol/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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