Multi-kinase inhibitor (VEGFR/FGFR/RET/KIT)
Lenvatinib (Specialist drug)
Brand names: Kisplyx, Lenvima
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: OD
Clinical pearls
- Differentiated thyroid cancer, RCC, HCC, endometrial cancer; specialist oncology
Contraindications
- Severe hepatic impairment
- See SmPC
Side effects
- Hypertension
- Proteinuria
- Hand-foot skin reaction
- Diarrhoea
- Hypothyroidism
- Cardiotoxicity
- Bleeding/thromboembolism
- GI perforation
Interactions
- Strong CYP3A4 modulators
- Anticoagulants
Monitoring
- BP
- TFTs
- Urine dipstick
- LFTs
Reference: BNF; NICE TA535/TA551/TA519; SmPC; https://bnf.nice.org.uk/drugs/lenvatinib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
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