Alkylating cytotoxic
Mitomycin (Specialist drug)
Brand names: Mitomycin Kyowa, Jelmyto
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV/Intravesical/Topical
Frequency: per protocol
Clinical pearls
- Bladder cancer (intravesical), GI/breast cancer (IV), upper-tract urothelial (Jelmyto)
Contraindications
- Severe myelosuppression
- Severe renal impairment
- Pregnancy
Side effects
- Severe delayed myelosuppression
- HUS / TTP
- Pulmonary toxicity
- Hepatotoxicity
- Cardiotoxicity
- Vesicant on extravasation
Interactions
- Live vaccines
- Other myelosuppressants
Monitoring
- FBC
- U&E
- LFTs
- Pulmonary function
Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/mitomycin-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
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- Recurrent UTI in Women · NICE NG112 / CKS; EAU 2024