Multi-kinase inhibitor (VEGFR/PDGFR/c-KIT)
Pazopanib (Specialist drug)
Brand names: Votrient
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: OD
Clinical pearls
- Advanced RCC, advanced soft-tissue sarcoma
- Specialist oncology
Contraindications
- Severe hepatic impairment
- Concurrent strong CYP3A4 inducers
Side effects
- Hepatotoxicity (severe — black box)
- Hypertension
- Diarrhoea
- QT prolongation
- Bleeding
- GI perforation
- Hypothyroidism
- Hand-foot syndrome
Interactions
- Strong CYP3A4 modulators
- QT-prolonging drugs
- Anticoagulants
Monitoring
- LFTs
- BP
- TFTs
- ECG
Reference: BNF; NICE TA215/TA465; SmPC; https://bnf.nice.org.uk/drugs/pazopanib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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