Multi-kinase inhibitor (RET, EGFR, VEGFR)
Vandetanib (Specialist drug)
Brand names: Caprelsa
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: OD
Clinical pearls
- Symptomatic medullary thyroid cancer
- Specialist oncology — Caprelsa REMS-style monitoring
Contraindications
- Severe hepatic impairment
- QT prolongation
- Pregnancy
- Hypersensitivity
Side effects
- QT prolongation (boxed)
- Diarrhoea
- Hypertension
- Severe skin reactions
- Hypothyroidism
- ILD
Interactions
- QT-prolonging drugs
- Strong CYP3A4 inducers
Monitoring
- ECG
- Electrolytes
- BP
- TFTs
- LFTs
Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/vandetanib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Sequential Organ Failure Assessment (SOFA) Score · Sepsis / Organ Failure
- Vancomycin Dosing Calculator · Drug Dosing
- Phenytoin Correction for Albumin / Renal Failure · Drug Dosing
- Local Anaesthetic Maximum Dose Calculator · Drug Dosing
- Multiple Organ Dysfunction Score (MODS) · Organ Failure Assessment
- Logistic Organ Dysfunction Score (LODS) · ICU Scoring
Pathways
- Diabetic Ketoacidosis (DKA) · JBDS 2013 / Joint British Diabetes Societies; NICE NG17
- Adult Hypoglycaemia (Treated Diabetes) · JBDS-IP (2023): Hospital Management of Hypoglycaemia
- Adrenal Crisis · Society for Endocrinology Emergency Guidance (2024)
- Type 2 Diabetes Management · NICE NG28 2022
- Hyperthyroidism Management · BTA / ETA 2018
- Adrenal Insufficiency · Society of Endocrinology / ESE 2016